{"id":12960,"date":"2026-10-19T08:00:00","date_gmt":"2026-10-19T08:00:00","guid":{"rendered":"https:\/\/jodoco.com\/?p=12960"},"modified":"2026-08-03T07:39:45","modified_gmt":"2026-08-03T07:39:45","slug":"how-to-prevent-necrotic-enteritis-in-broilers","status":"publish","type":"post","link":"https:\/\/jodoco.com\/en\/how-to-prevent-necrotic-enteritis-in-broilers\/","title":{"rendered":"How to prevent necrotic enteritis in broilers?"},"content":{"rendered":"<p>Necrotic enteritis in broilers can be prevented by actively protecting gut health through nutrition, management, and hygiene. The disease occurs when <em>Clostridium perfringens<\/em> gains the upper hand in a compromised gut, often as a result of coccidiosis or an unfavorable diet. In this article, we answer the most frequently asked questions about causes, recognition, and prevention.<\/p>\n<h2>What causes necrotic enteritis in broilers?<\/h2>\n<p>Necrotic enteritis in broilers is caused by an overgrowth of the bacterium <em>Clostridium perfringens<\/em> in the small intestine. This bacterium produces toxins that damage the intestinal wall and cause necrosis of intestinal tissue. The bacterium is normally present in small numbers in the gut, but gets the opportunity to proliferate when the intestinal balance is disrupted.<\/p>\n<p>Several factors promote this disruption. A diet rich in poorly digestible proteins, such as fishmeal or certain grain types, increases the amount of undigested protein in the gut. This provides a substrate for <em>Clostridium perfringens<\/em>. A high content of non-starch polysaccharides (NSP) in the feed also increases the viscosity of the intestinal contents, which stimulates bacterial growth.<\/p>\n<p>In addition to nutrition, management and environmental factors play a role: high stocking density, poor litter quality, stress from relocations or vaccinations, and the use of antibiotics that disrupt the microbiome. All these factors can tip the balance in the gut toward dysbiosis, where <em>Clostridium perfringens<\/em> takes over.<\/p>\n<h2>Which symptoms indicate necrotic enteritis in a flock?<\/h2>\n<p>Necrotic enteritis in a broiler flock can be recognized by a sudden increase in mortality, lethargy, reduced feed intake, and dark brown or bloody diarrhea. The disease sometimes progresses so rapidly that chicks are found dead without any obvious prior signs of illness. Subclinical forms are harder to recognize but are at least equally damaging to performance.<\/p>\n<p>During a clinical outbreak, you will observe the following signs:<\/p>\n<ul>\n<li>Sudden increase in daily mortality, sometimes more than 1% per day<\/li>\n<li>Chicks that stand apart, appear drowsy, and no longer walk to feed or water<\/li>\n<li>Wet, dark, or bloody droppings and deteriorating litter quality<\/li>\n<li>At necropsy: yellowish-brown or greenish patches on the intestinal wall, typical &#8220;Turkish towel&#8221; structure of the intestinal epithelium<\/li>\n<li>Unpleasant odor in the house due to increased putrefaction in the gut<\/li>\n<\/ul>\n<p>The subclinical form does not manifest as increased mortality, but does result in a deteriorated feed conversion ratio (FCR), slower growth, and uneven flocks. This form is often only noticed at the final settlement at the slaughterhouse. Early recognition of clinical signs is therefore crucial to prevent further deterioration.<\/p>\n<h2>How does coccidiosis increase the risk of necrotic enteritis?<\/h2>\n<p>Coccidiosis significantly increases the risk of necrotic enteritis because Eimeria parasites damage the intestinal wall, thereby clearing the way for <em>Clostridium perfringens<\/em>. The damage to the intestinal villi reduces the barrier function of the intestinal epithelium, increases permeability, and creates ideal conditions for bacterial overgrowth. The combination of coccidiosis and necrotic enteritis is therefore one of the most common and damaging disease syndromes in poultry farming.<\/p>\n<p>Eimeria infections disrupt the tight junctions between intestinal cells. These protein connections keep the intestinal barrier intact and prevent pathogens and toxins from entering the bloodstream. When these connections weaken, <em>Clostridium<\/em> toxins can penetrate more deeply and cause greater damage.<\/p>\n<p>Effective coccidiosis prevention is therefore one of the most important pillars in the prevention of necrotic enteritis. This can be achieved through coccidiostats in the feed, but also through nutritional interventions that strengthen intestinal integrity, such as betaine, butyrate, and medium-chain fatty acids (MCFA). Betaine is particularly valuable as an osmolyte: it reduces epithelial stress, strengthens tight junction proteins such as occludin and claudin-1, and thereby supports the gut&#8217;s resistance to infection.<\/p>\n<h2>Which nutritional measures reduce the risk of an outbreak?<\/h2>\n<p>The risk of a necrotic enteritis outbreak can be reduced through targeted nutritional measures that strengthen gut health and inhibit the growth of <em>Clostridium perfringens<\/em>. The most effective approach combines multiple mechanisms of action: barrier protection, pH reduction in the gastrointestinal tract, and support of a favorable microbiome.<\/p>\n<p>Specific nutritional measures include:<\/p>\n<ol>\n<li><strong>Adding betaine:<\/strong> Betaine strengthens the intestinal barrier via tight junction proteins, acts as an osmolyte and antioxidant, and reduces epithelial stress. Studies show that betaine improves resistance to coccidiosis and secondary bacterial infections.<\/li>\n<li><strong>Organic acids:<\/strong> Formic acid, propionic acid, and acetic acid lower the pH in the gastrointestinal tract and inhibit gram-positive and gram-negative pathogens such as <em>Clostridium perfringens<\/em> and <em>Salmonella<\/em>.<\/li>\n<li><strong>Butyrate:<\/strong> This short-chain fatty acid feeds the enterocytes, stimulates mucus production, and strengthens intestinal wall integrity. Slow-release butyrate reaches the small intestine more effectively.<\/li>\n<li><strong>MCFA (medium-chain fatty acids):<\/strong> Caprylic acid (C8), capric acid (C10), and lauric acid (C12) have strong antimicrobial activity, specifically against gram-positive bacteria such as <em>Clostridium perfringens<\/em>.<\/li>\n<li><strong>Yeast cell walls (beta-glucans and MOS):<\/strong> These prebiotics bind pathogens in the gut and stimulate the immune system, reducing the risk of dysbiosis.<\/li>\n<li><strong>Phytogenics and essential oils:<\/strong> Oregano and garlic have antimicrobial and anti-inflammatory properties that support the gut flora.<\/li>\n<\/ol>\n<p>A dietary adjustment that limits the amount of poorly digestible protein is also worthwhile. Less undigested protein in the gut means less substrate for <em>Clostridium perfringens<\/em>. Also take a look at our <a href=\"https:\/\/jodoco.com\/en\/drinking-water-and-feed-additives-animals\/\">drinking water and feed additives for animals<\/a> for specific product options that support this approach.<\/p>\n<h2>When is veterinary treatment necessary for necrotic enteritis?<\/h2>\n<p>Veterinary treatment is necessary for necrotic enteritis when daily mortality increases, chicks show clinical signs of illness, or necropsy reveals clear intestinal lesions. In such cases, rapid diagnosis and treatment by a veterinarian is essential to limit further spread and economic damage.<\/p>\n<p>In most cases, the veterinarian will perform a necropsy to confirm the diagnosis. Treatment traditionally consists of antibiotics, but due to the increasing &#8220;No Antibiotic Ever&#8221; (NAE) policy and the pressure of antibiotic resistance, more and more livestock farmers are looking for alternatives. In an NAE context, prevention therefore carries more weight than curative treatment.<\/p>\n<p>Always consult a veterinarian in the case of:<\/p>\n<ul>\n<li>Daily mortality of more than 0.5 to 1% of the flock<\/li>\n<li>Rapid deterioration of the general condition of the flock<\/li>\n<li>Bloody or severely abnormal droppings combined with lethargy<\/li>\n<li>Necropsy findings indicating necrotic intestinal lesions<\/li>\n<\/ul>\n<p>After an outbreak, it is advisable to draw up a prevention protocol together with the veterinarian and nutritionist to prevent recurrence. Products based on <a href=\"https:\/\/jodoco.com\/en\/betaine\/\">betaine<\/a> can play a valuable role here as a supportive measure alongside veterinary advice.<\/p>\n<h2>How do you set up an effective prevention protocol for your flock?<\/h2>\n<p>An effective prevention protocol for necrotic enteritis in broilers combines hygiene measures, nutritional interventions, and consistent monitoring of gut health. The protocol must be tailored to your specific house, diet, and risk periods, and should preferably be drawn up in consultation with a nutritionist and veterinarian.<\/p>\n<p>Start with a risk assessment of your current situation: what diet do you use, what is the litter quality like, have you had previous outbreaks? Based on this, you draw up a protocol that intervenes preventively before problems arise.<\/p>\n<p>Key components of a good prevention protocol are:<\/p>\n<ul>\n<li><strong>House cleaning and disinfection<\/strong> between flocks, with attention to Eimeria oocysts that are heat-resistant<\/li>\n<li><strong>Litter management:<\/strong> dry and loose litter reduces the infection pressure<\/li>\n<li><strong>Diet optimization:<\/strong> limit poorly digestible protein and add gut-supporting additives<\/li>\n<li><strong>Preventive use of drinking water products<\/strong> during risk periods (for example after vaccination or during heat stress)<\/li>\n<li><strong>Monitoring of mortality and FCR<\/strong> per week for early detection<\/li>\n<li><strong>Coccidiosis prevention<\/strong> as the foundation for the prevention of necrotic enteritis<\/li>\n<\/ul>\n<p>Drinking water is a particularly suitable delivery vehicle for preventive additives. Water intake in chicks is more reliable than feed intake, especially during stress or illness. This ensures that active substances reach the animal precisely when it is most needed. For this, also explore the possibilities of <a href=\"https:\/\/jodoco.com\/en\/producten\/grovax\/\">Grovax<\/a>, a combination product with organic acids, butyrate, and MCFA.<\/p>\n<h2>How Jodoco helps with the prevention of necrotic enteritis<\/h2>\n<p>At Jodoco, we have been developing scientifically substantiated feed and drinking water products for optimal gut health in broilers for more than 25 years. Our approach combines multiple mechanisms of action in one formula, so that you broadly protect the gut health of your flock, even in challenging conditions such as heat stress, coccidiosis, or an NAE strategy.<\/p>\n<p>Our products that specifically contribute to the prevention of necrotic enteritis:<\/p>\n<ul>\n<li><strong>Jodobet:<\/strong> Natural betaine as an osmolyte, methyl donor, and barrier protector. Strengthens tight junction proteins and improves the resistance of the intestinal wall against infection and stress.<\/li>\n<li><strong>Grovax:<\/strong> Combination of organic acids, slow-release butyrate, MCFA, and essential oils. Combats gram-negative and gram-positive pathogens, strengthens intestinal integrity, and fits within an NAE strategy.<\/li>\n<li><strong>Jodoplume:<\/strong> Liquid combination of betaine, organic acids, and copper for application via drinking water. Ideal during heat stress or coccidiosis periods from week 3 onwards.<\/li>\n<\/ul>\n<p>Would you like to know which prevention protocol best suits your flock and farm situation? <a href=\"https:\/\/jodoco.com\/en\/contact\/\">Contact our team<\/a> for personalized advice tailored to your needs.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Necrotic enteritis in broilers can be prevented by actively protecting gut health through nutrition, management, and hygiene. The disease occurs [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":12870,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-12960","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-geen-onderdeel-van-een-categorie"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>How to prevent necrotic enteritis in broilers? 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